Ebru Dirikgil, Jolijn R. van Leeuwen, Laura S. van Dam, Obbo W. Bredewold, Argho Ray, Jacqueline T. Jonker, Darius Soonawala, Hilde H.F. Remmelts, Bastiaan van Dam, Willem J. Bos, Cees van Kooten, Joris Rotmans, Ton Rabelink, Y.K. Onno Teng. ExploriNg DUrable Remission with Rituximab in ANCA-associatEd vasculitis (ENDURRANCE trial): protocol for a randomised controlled trial. BMJ Open 2022;12:e061339.
Description of the ENDURRANCE trial, I have co-designed the trial setup and successfully submitted our proposal to the medical ethical committee in LUMC, designed the database in Castor and enrolled the first four patients.

Jolijn R. van Leeuwen, Obbo W. Bredewold, Laura S. van Dam, Stella, L. Werkman, Jacqueline T. Jonker, Mirande Geelhoed, Antonius P.M. Langeveld, Hilde H.F. Remmelts, Maud M. van den Broecke, Argho Ray, Ton J. Rabelink, Y.K. Onno Teng. Compassionate Use of Avacopan in Difficult-to-Treat Antineutrophil Cytoplasmic Antibody–Associated Vasculitis. Kidney Int Rep 2021 Dec 8;7(3):624-628.
I managed and treated one of the AAV patients that received compassionate use avacopan, including input of the clinical data and side-effects.

Eline J. Arends, Tineke Kraaij, Laura S. van Dam, Sylvia W.A. Kamerling, Paul van Daele, Edwin W. Bredewold, Argho Ray, Jaap A. Bakker, Uli Scherer, Tom Huizinga, Ton J. Rabelink, Cees van Kooten, Y.K. Onno Teng. Long-term effects of combined B-cell immunomodulation with Rituximab and Belimumab in severe, refractory SLE: two-year results. Nephrol Dial Transplant 2021 Jul 23;36(8):1474-1483.
Managed and treated several (n=~10) SLE patients in this study, and performed the highly sensitive flow cytometry experiments.

Laura S. van Dam, Ebru Dirikgil, Edwin W. Bredewold, Argho Ray, Jaap A. Bakker, Cees van Kooten, Ton J. Rabelink, Y.K. Onno Teng. PR3-ANCAs predict relapses in ANCA-associated vasculitis patients after rituximab. Nephrol Dial Transplant 2021 jul 23;36(8):1408-1417.
Designed and analyzed large cohort dataset of AAV patients that were treated in the LUMC from 2006 to 2018.

Laura S. van Dam, Jelle M. Oskam, Sylvia W.A. Kamerling, Eline J. Arends, Edwin W. Bredewold, Magda A. Berkowska, Jacques J.M. van Dongen, Ton J. Rabelink, Cees van Kooten, Y.K. Onno Teng. Highly Sensitive Flow Cytometric Detection of Residual B-Cells After Rituximab in Anti-Neutrophil Cytoplasmic Antibodies-Associated Vasculitis Patients. Front Immunol. 2020 Dec 15;11:566732.
One of my major PhD publications. For this study I enrolled and treated all 12 AAV patients in this study, performed and analyzed the highly sensitive flow cytometry of B-cells, developed in-house ANCA assays and developed and performed PBMC cultures to detect ANCA producing B-cells.

Laura S. van Dam, Zgjim Osmani, Sylvia W.A. Kamerling, Tineke Kraaij, Jaap A. Bakker, Uli Scherer, Ton J. Rabelink, Reinhard E. Voll, Tobias Alexander, David A. Isenberg, Cees van Kooten, Y.K. Onno Teng. A reverse translational study on the effect of rituximab, rituximab plus belimumab, or bortezomib on the humoral autoimmune response in SLE. Rheumatol 2020 Oct 1;59(10):2734-2745.
One of my major PhD publications, I coordinated the FOREUM collaboration between University College Londen, LUMC Leiden, Charite Berlin and University of Freiburg. I developed 4 in-house assays to detect SLE related autoantibodies, developed an avidity assay, applied my optimized NET-assay to measure NET formation in the different SLE cohorts, and collected and analyzed all the data.

Laura S. van Dam, Tineke Kraaij, Sylvia W.A. Kamerling, Ton J. Rabelink, Cees van Kooten, Y.K. Onno Teng. Intrinsically Distinct Role of Neutrophil Extracellular Trap Formation in Antineutrophil Cytoplasmic Antibody–Associated Vasculitis Compared to Systemic Lupus Erythematosus. Arthritis Rheumatol 2019 Dec;71(12):2047-2058.
One of my major and highly cited PhD publications, and breakthrough in the field demonstrating that NETs are intrinsically different in SLE as compared to ANCA-associated vasculitis patients. I performed the immunohistochemistry stainings of NETs, data analysis and manuscript preparation.

Laura S. van Dam, Eline J. Arends, Tineke Kraaij, Sylvia W.A. Kamerling, Ton J. Rabelink, Cees van Kooten, Y.K. Onno Teng. A high-throughput assay to assess and quantify neutrophil extracellular trap formation. J Vis Exp 2019 Jan;143, e59150.
This article describes the full protocol of the high throughput assay of my optimized assay to quantify neutrophil extracellular trap formation, and provides an educational video on the procedures.

Laura S. van Dam, Ton J. Rabelink, Cees van Kooten, Y.K. Onno Teng. Clinical implications of excessive neutrophil extracellular trap formation in renal autoimmune diseases. Kidney Int Rep 2018 Nov 19;4(2):196-211.
I reviewed the literature on NETs in SLE and ANCA-associated vasculitis.

Tineke Kraaij, Sylvia W.A. Kamerling, Laura S. van Dam, Jaap A. Bakker, Ingeborg M. Bajema, T Page, F Brunini, Charles D. Pusey, Rene E.M. Toes, H. Uli Scherer, Ton J. Rabelink, Cees van Kooten C, Y.K. Onno Teng. Excessive neutrophil extracellular trap formation in ANCA-associated vasculitis is independent of ANCA. Kidney Int 2018 Jul;94(1):139-149.
My contribution to this article included immunofluorescence stainings of NETs in AAV patients. This article was highlighted in a commentary and on the journal cover of Kidney International.

Anke van Erp, Yvonne M.H. Versleijen-Jonkers, Melissa Hillebrandt-Roeffen, Laura S. van Dam, Thomas Mentzel, Marije Weidema, Winette van der Graaf, Uta Flucke, Friederike AG. Meyer-Wentrup. Expression and clinical association of PD-1, PD-L1 and CD8+ lymphocytes in primary sarcomas is subtype dependent. Oncotarget 2017 Jul 7;8(41):71371-71384.
Scientific master internship (9 months). Performed the staining analysis of PD-1 and PD-L1 in primary sarcomas.

Anouk A.J. Hamers, Laura S. van Dam, José M. Teixeira Duarte, Mariska Vos, Goran Marinković, Claudia M. van Tiel, Sybren L Meijer, Anje A te Velde, Wouter de Jonge, Carlie J.M. de Vries. Deficiency of Nuclear Receptor Nur77 aggravates mouse experimental colitis by increased NFκB activity in macrophages. PloS ONE 2015;10:e0133598.
Scientific bachelor internship (5 months). Performed immunohistochemistry staining experiments, mRNA isolation and qPCR for colon tissue of Nur77-/- mice and analyzed the data.

Laura S. van Dam, Vera M. de Zwart, Frederike A.G. Meyer-Wentrup. The Role of Programmed Cell Death-1 (PD-1) and Its Ligands in Pediatric Cancer. Pediatric Blood & Cancer 2015 Feb;62(2):190-197.
Master thesis project (2 months), for which I reviewed the literature regarding the role of PD-1 in pediatric cancer, analyzed the data and wrote the article.